CD44 and metastatic malignant neoplasm in the lymph nodes: Of the 25 CD44-positive cases, 14 (56%) were considered H-IRS (Figure 1 and Figure 2), and, in 7 of these cases, there was locoregional lymph node metastases at the time of diagnosis; 11 (44%) were considered L-IRS, and, in 5 of these cases, there was locoregional lymph node metastases at the time of diagnosis.