Thyroid cancer cell lines overexpressing TUSC2 demonstrate a significant increase in SMAC/DIABLO and cytochrome C expression following treatment with an apoptosis inducer, suggesting that TUSC2 sensitizes thyroid cancer cells to apoptosis via upregulation of SMAC/DIABLO and cytochrome C [18]. The gene discussed is TUSC2; the disease is thyroid gland carcinoma.