Interestingly, although TUSC2 protein expression is reduced in the majority of lung cancer samples, TUSC2 mRNA is expressed in the majority of lung cancer samples, with less than 20% of patients having TUSC2 promoter methylation, suggesting that TUSC2 expression is post-transcriptionally altered in lung cancers [61,63]. This evidence concerns the gene TUSC2 and lung carcinoma.