TUSC2 and glioblastoma: In our control and TUSC2-KO GBM cell lines, treatment with the Bcl-xL specific BH3 mimetic A-1331852 led to a significant increase in apoptosis only in TUSC2 positive cells, indicating an important connection between TUSC2-mediated apoptosis and Bcl-xL activity in GBM [11].