A myriad of cytokines circulate in the TME, promoting both anti-oncogenic and pro-oncogenic states; however, the most important factors surrounding BCC lesions include the cytokines interferon gamma (IFN-γ), TGF-β, IL-6, IL-10, and CCL22 (Figure 2) [18,26]. Here, IL6 is linked to skin basal cell carcinoma.