Reshaped tumor microenvironment and peripheral blood is featured by increased CD8 T cells, conventional CD4 T cells, NK cells, dendritic cells, and M1-skewed tumor-associated macrophages and decreased Tregs, myeloid-derived suppressive cells, M2-skewed tumor-associated macrophages, and anti-tumor cells near to tumor cells spatially. The gene discussed is CD4; the disease is neoplasm.