CAFs are also known to recruit and polarize macrophages in a CSF1–CSF1R dependent manner, but low levels of the CSF1–CSF1R interaction did not change with treatment in pancreatic cancer, while the interaction between CXCL12 (on iCAFs but not myCAFs) and CXCR4 (on both TAM subpopulations) significantly weakened with treatment [33,121]. Here, CSF1 is linked to familial pancreatic carcinoma.