In addition, platinum-based chemotherapy could decrease the phosphoglycerate dehydrogenase (PHGDH) level to decrease serine biosynthetic activity but, simultaneously, regenerate oxidized nicotinamide adenine dinucleotide (NAD+), which helps tumor cells in sustaining poly (ADP-ribose) polymerase (PARP) activity under treatment [64]. Here, PHGDH is linked to neoplasm.