The Hippo pathway effector YAP1 is a potent transcriptional coactivator and forms a complex with ZEB1 to activate integrin α3 transcription through the YAP1/transcriptional enhanced associate domain (TEAD) binding sites in human pancreatic cancer cells, leading to pancreatic cancer metastasis and EMT plasticity [83]. The gene discussed is ZEB1; the disease is familial pancreatic carcinoma.