TIMP1 and familial pancreatic carcinoma: The expression of certain proteins, such as leucine-rich alpha-2 glycoprotein 1 (LRG1), tissue inhibitor of metalloproteinase 1 (TIMP-1), calcium and integrin binding 1 (CIB1), and macrophage inhibitory cytokine 1 (MIC1), have been identified as potential biomarkers for the early detection of pancreatic cancer (Figure 1) [14,21,22].