Ideally, to dissect the precise subpopulations of CB1Rs involved, these experiments should be conducted with (i) different doses of a CB1R-selective antagonist and a CB1R-selective agonist (plus their vehicle control); (ii) various lines of age-matched, genetically-modified mice (at least Glu-CB1R-KO and GABA-CB1R-KO mice, plus their CB1R-floxed littermates); and (iii) CB1R-WT and CB1R-KO melanoma cells. This evidence concerns the gene CNR1 and melanoma.