CNR1 and neoplasm: When assessing the status on NMDAR-associated signalling in tumour cells, we found that the expression of PSD-95, a protein essential to ensure NMDAR localization on surface membranes and post-synapses [42], was also selectively increased in tumours from Glu-CB1R-KO animals, thus supporting that a glutamate-NMDAR signalling axis fosters melanoma cell proliferation (Figure 5A).