The proportion of germline BRCA2 mutation carriers among patients with any stage PC was available from 30 articles, for a total of 29,813 patients, and was equal to 3.25% (95% CI: 2.54–4.04), with significant heterogeneity (I2 = 90.96%; p < 0.0001) (Figure 3a). Here, BRCA2 is linked to pachyonychia congenita.