CD8A and neoplasm: CD8α+ DCs, a subset of conventional DCs type 1, are crucial for the cross-presentation of extracellular tumor antigens on MHC I molecules to cytotoxic CD8+ T cells, which subsequently recognize target cells and trigger apoptosis through the release of granzyme B and perforins or through activation of death receptor signaling (i.e., Fas/FasL) [37,38].