The results of the 4-Hydroxynonenal (4-HNE) staining of the tumor samples showed that the overexpression of NAMPT reversed the induction of the ferroptosis program by NAM after high-dose NMN treatment, whereas NAM-restored cells, combined with the NAMPT inhibitor FK866, subsequently restarted the ferroptosis program (Figure 6F). This evidence concerns the gene NAMPT and neoplasm.