α‐Mangostin has been shown to inhibit the expression of stemness-related genes CD24, CD44, CD133, NANOG, OCT4, c‐Myc, SOX2, and KLF4 by inhibiting the GLI transcription, indicating that it can regulate cancer growth by inhibiting cancer stemness population [51]. Another GLI transcription factor inhibitor GANT-61 is able to block DNA binding of GLI and decreases transcriptional activity of pluripotency-promoting factors in PCSCs, thereby reducing cancer cell growth and proliferation [52, 53]. The gene discussed is PROM1; the disease is cancer.