In PC, in vitro experiments have demonstrated that RER1 promotes stemness in a hypoxic environment, including enhancing tumorsphere formation ability and stemness markers expression such as CD133, SOX2, BMI-1, Lin28, and NANOG, but the specific effect of RER1 on NOTCH signaling in PC still needs to be further explored [98]. Here, RER1 is linked to pachyonychia congenita.