Paracrine HGF induces YAP nuclear translocation by binding c-MET, resulting in the crosstalk between CAFs and cancer cells that HGF/c-MET-mediated induces the expression of stemness pluripotency markers such as NANOG, OCT4, and SOX2 in PC cells, as well as increased self-renewal ability [146]. This evidence concerns the gene SOX2 and cancer.