As shown in Table 3 and Fig. 2, SLE onset age≤30 (HR 1.616, 95%CI 1.067–2.449, p=0.023), arthritis (HR 1.642, 95%CI 1.089–2.475, p=0.018), existing organ damage (SDI≥1) at registration (HR 2.610, 95%CI 1.748–3.895, p<0.001), positive anti-RNP (HR 1.709, 95%CI 1.162–2.515, p=0.006), and high glucocorticoid maximum daily dose at registration (HR 1.747, 95%CI 1.092–2.795, p=0.02) were independent risk factors for AVN development. The gene discussed is RNPC3; the disease is avascular necrosis.