In addition to these cases, in previous studies, the relationship between periostin level and diabetic retinopathy [31], renal injury [32], coronary heart disease [23], smoking [33], etc. has been shown while it was not possible to adjust these variables in the current study and the presence of people with this diseases and risk factors among the study groups can have an impact on the estimation. Here, POSTN is linked to coronary artery disorder.