Importantly using the Chiang molecular classification of HCC [39], we observed that TCGA liver tumors hypermethylated at NSUN7 were significantly enriched in the CTNNB1 subclass (Fisher’s exact test, P = 0.011) and it has been recently proposed that β-catenin activation in HCC promotes resistance to anti-PD-1 therapy [40]. Here, CTNNB1 is linked to hepatocellular carcinoma.