After adjusting for clinicopathological factors (including age, gender, histological subtype, tumor diameter and lymph node status), multivariate Cox models demonstrated that low CCPS of CD8+ Ttotal in IM [HR = 0.54; 95%CI (0.34-0.86); P = 0.009] and high CCPS of CD8+ Tdys in IM [HR = 1.65; 95%CI (1.14-2.38); P = 0.017] maintained significant correlations with poor RFS that also existed in univariate models and survival analysis (Additional file 1: Figures S7, S8). This evidence concerns the gene CD8A and neoplasm.