HIF1A and cancer: We observed more CMVs around hypoxic cancer cells (pan-CK+/Hif-1α+) than normoxic cancer cells (pan-CK+/Hif-1α−) in both IM and TC, which supported the hypothesis that hypoxia in cancer cells could induce angiogenesis (Fig. 5e), whereas no significant difference was observed hin the analysis of CAFs (Fig. 5f).