CD8A and neoplasm: After adjusting for clinicopathological factors (including age, gender, histological subtype, tumor diameter and lymph node status), densities of CD8+ Ttotal in IM [HR = 0.57; 95%CI (0.35–0.92); P = 0.021], CD8+ Tpredys in TC [HR = 0.55; 95%CI (0.34–0.89); P = 0.014] and CD8+ Tdys in IM [HR = 2.49; 95%CI (1.60–4.13); P = 0.012] remained significantly associated with RFS (Additional file 1: Figure S3).