CD8A and neoplasm: In multivariate Cox models, shorter mNND (CD8-Treg) in IM [HR = 1.72; 95%CI (1.26–2.92); P = 0.024] and shorter mNND (CD8-CAF) in IM [HR = 1.57; 95%CI (1.11–2.43); P = 0.024] were still significant associated with worse RFS after adjusting for clinicopathological factors (including age, gender, histological subtype, tumor diameter and lymph node status) (Additional file 1: Figures S5, S6).