Since elevated levels of CD163 are not only obtained from plasma samples of FD patient but are also reported in Gaucher disease or endomyocardial biopsies from patients with myocardial diseases [88, 89] the higher expression of CD163 on CX3CR1+ and/or CD11b+cells may resemble a compensatory reaction to resolve accumulating lipids and cell debris common to LSDs. Here, CX3CR1 is linked to Gaucher disease.