TRPV1 and Fabry disease: All models display abnormalities resembling human FD, including Gb3 accumulation in the peripheral nervous system, alterations in sensorimotor function, hyposensitivity to painful stimuli, as well as upregulation of the transient receptor potential cation channel subfamily V member 1 (TRPV1) and voltage-gated sodium (Nav1.8) channels [15, 25, 27, 36, 37].