Considering the significant changes and high expression level of FOSL2 in HepLPC-P10 (Figs. 5E and 6A), FOSL2 was selected to perform interference experiments with short hairpin RNA-mediated FOSL2 (shFOSL2) knockdown via lentiviral infection to verify its effect on the aging of HepLPCs. The gene discussed is FOSL2; the disease is infection.