Data from us and other laboratories reveal the intrinsic linking between circRNA and breast cancer [10], for example, circBGN was upregulated in HER2-positive breast cancer and conferred trastuzumab resistance through repressing SLC7A11-mediated ferroptosis [11]; circTRIO was identified as a potential oncogenic regulator in TNBC, which regulated the miR-432-5p/CCDC58 axis [12]. The gene discussed is ERBB2; the disease is breast cancer.