IL18 and polycystic ovary syndrome: The chronic low-level inflammation associated with PCOS generally does not show any obvious symptoms such as local redness or fever, but can result in the secretion of inflammatory factors, mainly characterized by elevated concentrations of C-reactive protein (CRP), tumor necrosis factor, interleukin 18 (IL-18), IL-6, white blood cell count, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, etc.99.