GNRH1 and early-onset autosomal dominant Alzheimer disease: By screening the significantly enriched KEGG signaling pathways, the target genes regulated by the EV-miRNAs become mainly enriched in metabolic, calcium signaling, GnRH signaling and VEGF signaling pathways; long-term enhancement mechanism (long-term potentiation, or LTP); dopaminergic and cholinergic synapse; Alzheimer’s disease (AD); and glutathione, glycerophospholipid, and arachidonic acid metabolism, among others (Fig. 6).