S100A6 and essential hypertension: A subgroup analysis of the ESAX-HTN study showed that in patients with essential hypertension, decreases in office BP were numerically greater in female patients, patients aged ≥65 years, patients with low body mass index (<25 kg/m2), and patients with lower baseline levels of PAC (<120 pg/ml) and PRA (<1.0 ng/ml/h) [24].