The safety of ACT is very important because of the potential for on-target/off-tumor, off-target and CRS toxicities; indeed, the on-target/off-tumor toxicities caused by CAR-T cells directed against HER2 [27] or a transgenic TCR directed against MAGE-13 protein led to respiratory failure and neurotoxicity [28]. Here, ERBB2 is linked to neoplasm.