Colorectal Neoplasia Differentially Expressed (CRNDE) is an lncRNA located at the atypical locus hCG_1815491 on chromosome 16, adjacent to the IRX5 gene, sharing the same bidirectional promoter, and was first named for its upregulated expression in colorectal cancer (CRC)46,47.CRNDE has been reported to be highly expressed in a variety of cancers, such as hepatocellular carcinoma, lung cancer, renal cell carcinoma, and glioma48. Here, IRX5 is linked to hepatocellular carcinoma.