P2RX7 and Anxiety: As we mentioned before, only a very few studies, and usually not primarily focusing on anxiety, have reported results on the potential role of the P2RX7 gene in anxiety, and none of them considered the possible interacting role of stress, although in one previous study rs208294 was found to be associated with mood disorder outcomes in a relationship mediated by neuroticism, a personality trait which is associated with less adaptive responses and increased anxiety upon exposure to stress24.