Here we show exaggerated SBP elevation post epinephrine administration and subsequent pathological findings similar to HF using mice overexpressing GRK2 in the vessels generated by intraperitoneal injection of adeno-associated virus (AAV) vectors under the control of myosin heavy chain 11 (Myh11), accompanied by induction of β-AR signaling uncoupling. The gene discussed is GRK2; the disease is hydrops fetalis.