It has been shown that adipose tissue in obese individuals infiltrates with macrophages that promote and secrete systemic pro-inflammatory mediators such as tumor necrosis factor-α, leptin, but reduces adiponectin, and this causes inflammation in the airway, and leads to increases airway hyperresponsiveness and may contribute to asthma in persons who are obese44. The gene discussed is ADIPOQ; the disease is asthma.