We also investigated the role of WNT5A in the PRMT2 facilitation of the EMT process, and western blot assays showed that Snail-1 and N-cadherin increased while E-cadherin decreased after ectopic expression of WNT5A in PRMT2-knockdown RCC cells (Fig. 5G, H). This evidence concerns the gene CDH2 and renal cell carcinoma.