PRP preparations are available in the form of injections,8powder,9and gel.10Several studies showed that the PRP injection in non-healing oral ulcers achieved complete epithelialization after 8 weeks.8In the case of oral ulcers caused by oral pemphigus vulgaris, the healing process took 8 weeks to 24 months.11, 12Due to a lack of information about the PRP's effects on traumatic ulcer healing, especially in diabetes mellitus, the current study analyzed the PRP influence on TGF-β1 and MMP-9 expression in traumatic ulcers and considered it a good material for traumatic ulcer therapy. This evidence concerns the gene MMP9 and Oral ulcer.