Published literature has reported the antagonistic roles of these two cytokines with each other as Moretti et al and Sun et al44, 45have described a dampening effect of IL-10 on the expression of IL-17 and indicating the protective role of IL-10 in suppressing an IL-17 periodontitis trait and the upregulation of IL-17 inflammatory responses in the condition of IL-10 deficiency. This evidence concerns the gene IL10 and periodontitis.