Our previous study showed that ORP4L promotes phospholipase C β3 (PLCβ3) translocation from the nucleus to the PM (22) and forms a PLCβ3-Gαq/11-CD3ε complex that activates PLCβ3 upon anti-cluster of differentiation 3 (CD3) stimulation, regulating IP3 production and ER Ca2+ release in T-ALL cells (23). The gene discussed is PLCB3; the disease is acute lymphoblastic leukemia.