ACE2 and neurodegenerative disease: In addition, ACE2 is a known essential modulator of therenin–angiotensin–aldosterone system,25−27 which has been found to be dysfunctional following SARS-CoV-2infection.28 Interestingly, studies have also demonstrated that ACE2expression increases with aging, which in turn might explain the predominance of severemorbidity and mortality in older subjects, as well as more predominant neurologicalmanifestations and acceleration of prior neurodegenerative diseases.29