INS and obesity due to melanocortin 4 receptor deficiency: For example, regarding metabolically healthy obesity, in the Tübingen Diabetes Family Study (TDFS), the metabolically healthy and insulin-sensitive obese individuals were found to differ in liver fat content, intramyocellular lipids, and VAT but not in body weight, height, or waist circumference (WC), from the metabolically unhealthy and insulin-resistant obese individuals (14).