KRAS and neoplasm: Both groups of tumors are high-grade adeno-squamous carcinoma sprouting invasive nests of tumor cells, but the AAV-K group (n = 5) shows more adeno-differentiation admixed with a lesser squamous component than the Lenti-KrasG12D cohort (n = 5) (Fig. 3, C and D), opposite to the tumor differences in FVB mice, suggesting that the precancerous state affects edited Kras versus overexpressed KrasG12D in specifying tumor characteristics.