While the Lenti-PIK3CAH1047R group (n = 5) exhibits prominent papillary differentiation with minimum squamous differentiation as we reported previously (33), the AAV-P group (n = 6) shows less papillary and other glandular differentiation, exhibits notable focal squamous differentiation, and is thus less differentiated overall (Fig. 3, E and F), suggesting that similar to the Kras case, edited Pik3ca and overexpressed PIK3CAH1047R may also drive tumor cell differentiation differently. The gene discussed is PIK3CA; the disease is neoplasm.