At the ethical end point of approximately 2.0 cm in diameter, both groups of tumors are high-grade adeno-squamous carcinoma sprouting invasive nests of tumor cells, but the AAV-K group (n = 4) appears to have progressed further into squamous carcinoma with extensive keratin production and little or no glandular presence compared to the Lenti-KrasG12D cohort (n = 8; Fig. 3, A and B), suggesting that edited Kras and overexpressed KrasG12D may drive tumor cell differentiation differently. This evidence concerns the gene KRAS and squamous cell carcinoma.