CD4 and acrodermatitis enteropathica: In this work, we found that LAG3 expression was predominantly found in the adaptive Treg (iTreg) lineage of AE patients, suggesting that LAG3 is primarily expressed on iTregs differentiated from peripheral naive CD4+ T cells rather than on natural Tregs (nTregs) generated by high-avidity interaction-based selection in the thymus [48].