The same effect was witnessed upon transfection of primary MM cells with αCD38‐ or iso‐tLNPs encapsulating siRNA to silence induced myeloid leukemia cell differentiation protein 1 (MCL1), where only αCD38‐tLNPs‐siRNA‐MCL1‐treated cells demonstrated a significant decrease in cell viability (Figure S2D, Supporting Information). This evidence concerns the gene MCL1 and Miyoshi myopathy.