While αCD38‐tLNPs‐siRNA‐CKAP5 induced 53.19% cell death of primary MM cells 72 h post‐tLNPs transfection, no notable therapeutic effect was visible in cells treated with either iso‐tLNPs‐siRNA‐CKAP5 or αCD38‐tLNPs‐siRNA‐NC (Figure 3J). Here, CKAP5 is linked to Miyoshi myopathy.