Consistent with the results of the present study in Atoh1‐Pex5−/− mice, BK α‐subunit knockout mice were also reported to show identical hearing loss phenotype.[57] Further, mutations in the BK‐encoding sol gene are a susceptibility factor for hearing loss in human.[56] Of note, Pejvakin genes were found to be potentially associated with peroxisome proliferation, and abnormalities in BK channels were detected in Pjvk−/− mice.[19] At this point, it is not clear whether the peroxisome deficiency affects BK channels directly or indirectly through another factor(s) or pathway(s). This evidence concerns the gene ATOH1 and hearing loss disorder.