METTL3 and esophageal cancer: During zebrafish embryogenesis, m6A modification on notch1a mRNA could repress Notch signaling to promote hematopoietic stem and progenitor cell specification.[50] In Hela cells, YTHDF2‐recognized m6A modification of Notch1 mRNA accelerates Notch1 mRNA degradation, whereas in esophageal cancer cells METTL3‐catalyzed m6A modification on Notch1 mRNA increases Notch1 expression and promotes Notch1 activation.[20, 21, 50, 51] Interestingly, by analyzing public m6A MeRIP‐seq odatasets of LUAD cells (GSE54365) (Figure 3A), no specific m6A modifications across Notch1 transcripts are found.