Impressively, circulating tumor cells (CTCs) isolated from stage IV LUAD patients with high IGF2BP3 levels displayed co‐expression of epithelial marker Keratin and mesenchymal marker Vimentin; the co‐expression of strong Keratin and Vimentin immunostaining were also detected in clinical tissues of bone metastases from LUAD patients (Figure 7F), indicating the presence of p‐EMT state in both LUAD CTCs and LUAD metastatic lesions. The gene discussed is IGF2BP3; the disease is neoplasm.