SIRT1 and cancer: IGF2BP3 directly recognizes m6A modified mRNAs of minichromosome maintenance complex component 5 (MCM5) gene, a member of an evolutionarily conserved MCM family assisting in loading DNA onto replication origins,[22, 23] to stabilize MCM5 mRNAs and to increase MCM5 protein expression, which binds NICD1, competitively abrogates SIRT1‐mediated NICD1 deacetylation and degradation, and potently induces cancer cell plasticity to facilitate metastasis in an m6A‐dependent manner.