MCM5 and neoplasm: In vivo, while subcutaneous xenografts of IGF2BP3‐overexpressing A549 cells displayed marked penetration of tumor cells into neighboring subcutaneous tissue, MCM5 depletion abrogated the penetrating ability of IGF2BP3‐overexpressing A549 cells in subcutaneous xenografts (Figure5A); MCM5 depletion also greatly impaired metastatic colonization of IGF2BP3‐overexpressing A549 cells when intravenously injected (Figure 5B–D).