Under ferroptosis's oxidative stress, cancer cells stimulate p62 (also known as SQSTM1) which promotes autophagic degradation of Kelch-like ECH-associated protein 1 (Keap1), resulting in a positive feedback loop of continuous nuclear factor E2-related factor 2 (Nrf2) activation to maintain oxidative homeostasis [8, 9]. The gene discussed is SQSTM1; the disease is cancer.