To further verify if upregulate of HOTAIRM1 can reverses lenvatinib-sensitive HCC to lenvatinib-resistance HCC, parental sensitive cells HepG2 and Huh7 were examined by use of the autophagic flux inhibitors CQ before and after overexpression of HOTAIRM1. The gene discussed is HOTAIRM1; the disease is hepatocellular carcinoma.