Interestingly, in our ALS cohort, there were two patients (Case No. 1901 and Case No. 1120) carrying two different missense variants in CCNF. Case No. 1901, who carried the p.Pro487Ser and p.Arg516Gln variants of CCNF (predictions were 2/8 and 5/8, respectively; the latter located in the cyclin domain was considered to be a PP missense variant), developed dysarthria at the age of 65 with a disease progression rate of 1.17 and died of nutritional problems 22.5 months after onset. This evidence concerns the gene CCNF and amyotrophic lateral sclerosis.