While demonstrated to be effective in many of these contexts, recent applications in AD animal models using repeated fractions of 0.5–2 Gy of x-irradiation have revealed benefits including reduced amyloid plaque load, reduced phosphorylated tau (p-tau), resistance to neuroinflammatory conditions, and increased neuron viability in concert with improved cognitive performance [21–26]. The gene discussed is MAPT; the disease is amyloidosis.