Taken together, enrichment in signalling pathways of the differentially expressed proteins highlights the overrepresented pathways modulated by exercise in prostate carcinogenesis, such as endocrine resistance, PI3K-AKT, FOXO, MAPK pathways, which may explain the greater weight of the prostate of trained PCa rats, compared with sedentary PCa animals. This evidence concerns the gene AKT1 and posterior cortical atrophy.