The protein–protein interaction network that was constructed with the proteins differentially regulated in the prostate from EX + PCa rats when compared with SED + PCa animals showed 25 nodes highly interconnected, with AKT1 and CTNNB1 as the most central ones for having more interactors (detailed analysis of the protein–protein interaction networks is presented as Supplementary information). Here, AKT1 is linked to posterior cortical atrophy.