Still, as previously Tau missorting was inducible shortly after stress induction in other paradigms (i.e., as soon as minutes to hours, with the peak usually around 3 h after stress induction Zempel et al. 2010; Zempel et al. 2013; Schützmann et al. 2021; Tjiang and Zempel 2022), one may conclude that simply physically ablating the axon via axotomy is insufficient to induce AD-like Tau missorting as observed previously. Here, MAPT is linked to Alzheimer disease.