MAPT and tauopathy: In these tauopathies, traumatic axon injury leads to Tau pathology, i.e. hyperphosphorylation, missorting, and aggregation, and ultimately widespread neurodegeneration (Dale et al. 1991; Tokuda et al. 1991; Ikonomovic et al. 2004; Uryu et al. 2007; Goldstein et al. 2012).