E. coli K1 also interacted with subpopulations of microglial cells transfected to express either Siglec-11 or Siglec-16, and after infection with E. coli K1 in vitro, more bacteria could be recovered from the Siglec-11 and less from the Siglec-16 transfected cells, as compared to controls transfected with empty vector [84]. This evidence concerns the gene SIGLEC16 and infection.