CASP8 and hepatocellular carcinoma: After the calculation of differential analysis, we observed that RIPK1, CASP6, CASP8, PYCARD, FADD, MAP3K7, TNFAIP3, RNF31, RBCK1, and PSTPIP2 were overexpressed in the HCC samples, nevertheless, the expression of NLRP3 was down expressed in the HCC samples (Figure 1A).