CTLA4 and hepatocellular carcinoma: Furthermore, giving the significant difference in immune infiltration, we further estimated the immunotherapy response of HCC in PAN-RG cluster A, B, and C. The IPS assessment analysis revealed that the HCC samples in the PAN-RG cluster C displayed a worse immunotherapy response to PD-1 and CTLA-4 than PAN-RG cluster A and B (Figure 3C–3F).