After the calculation of differential analysis, we observed that RIPK1, CASP6, CASP8, PYCARD, FADD, MAP3K7, TNFAIP3, RNF31, RBCK1, and PSTPIP2 were overexpressed in the HCC samples, nevertheless, the expression of NLRP3 was down expressed in the HCC samples (Figure 1A). The gene discussed is RNF31; the disease is hepatocellular carcinoma.