JUN and esophageal cancer: In addition, recent study showed that miR-493/Wnt5A/c-JUN regulatory axis as a novel feedback loop that affected the esophageal cancer development, and miR-493 regulated Wnt5A, inhibited c-JUN activity, and enhanced p21 expression, whereas c-JUN bonded to the upstream promoter region of miR-493 to suppressing miR-493 expression, then forming a vital negative feedback loop which provides potential targets for therapy of esophageal cancer [28].