Thus, in this study, we address the following questions: (a) whether miR-497 expression is associated with esophageal cancer incidence; (b) what the underlying role of miR-497 in tumor progression is; (c) whether miR-497 induces chemosensitivity to drug treatment in esophageal cancer; (d) what direct target of miR-497 is for regulating esophageal cancer; and (e) whether expression levels and correlation between miR-497/QKI may have the prognostic value in esophageal cancer, or be used for developing new prognostic markers and treatment option in the future. Here, QKI is linked to neoplasm.