HLA-DRB1 and hypersensitivity reaction disease: A recent study identified that frequencies of certain HLA alleles, including DRB1*15:02, were significantly higher in patients with ICM-related anaphylaxis in the Korean population.[14] A family history of ICM-related hypersensitivity reaction was also shown to predict occurrence of such a reaction, suggesting a potential genetic predisposition.[12] Therefore, as a single ethnic group, we considered it necessary to report the incidence and severity of ICM-related ADRs using only domestic data from the Republic of Korea.