DCD and breast cancer: In the present study, we found that compared with CRC, DCD showed a large fold change (log2 fold change: 11.7) in endometrial carcinoma (Fig. 3C), and an increase in DCD gene expression has been established to be associated with poor survival in breast cancer.[55] Considering the generally better prognosis of MSI-CRC than that of endometrial carcinoma, these findings are interesting.