The combination of previously obtained factors (age, history of CVD, diabetes, and eGFR) affecting the prognosis of all-cause mortality and common controversial HD risk factors (gender, smoking, β-blocker, statins, erythropoiesis stimulating agents, hypertension, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, CRP, calcium, phosphate, and iPTH) was named the traditional factors model, when the HALP was added to this model, named the traditional factors + HALP model. The gene discussed is CRP; the disease is Hypertension.