EVA1A and hepatocellular carcinoma: They can come from inside the cell, like Eva1a and ATP6V0D2.[39,54] Other cells and drugs can also control autophagy of hepatic macrophages such as HSC,[49] hepatic carcinoma cell,[45] empagliflozin, ezetimibe,[38] and lycopene.[53] Secondly, the downstream regulation of autophagy is also diverse.