RENBP and early-onset autosomal dominant Alzheimer disease: There were 9 signal pathways enriched in peripheral nerve injury, namely pathways of neurogenesis – multiple diseases, lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic composites, Kaposi sarcoma associated herpesvirus infection, IL-17 signaling pathway, PI3K Akt signaling pathway, MAPK signaling pathway, fluid shear stress and atherosclerosis, and Alzheimer disease.